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trans-Cinnamic acid

Name: trans-Cinnamic acid
Brand: TargetMol
SKU: T2740
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2740Cas No. 140-10-3

Alias trans-3-Phenylacrylic acid, Phenylacrylic acid, Isocinnamic acid, Cinnamylic acid, Cinnamic acid, 3-Phenylacrylic acid

trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.

trans-Cinnamic acid

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Purity: 99.63%

Catalog No. T2740Alias trans-3-Phenylacrylic acid, Phenylacrylic acid, Isocinnamic acid, Cinnamylic acid, Cinnamic acid, 3-Phenylacrylic acidCas No. 140-10-3

trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$39	In Stock	In Stock
500 mg	$60	In Stock	In Stock
1 g	$77	In Stock	In Stock
5 g	$113	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

trans-Cinnamic acid AI Summary

trans-Cinnamic acid exhibits a diverse range of bioactivities across various biological systems. This compound demonstrates significant gastric cytoprotective activity in male Wistar rats with a cytoprotective effect of 5.0 and inhibits beta-hexosaminidase release by 7.0% at 100 µM in RBL-2H3 cells. It also inhibits alpha-glucosidase and nitric oxide (NO) production in distinct assays with IC50 values exceeding 5000 µM and 100 µM respectively, with an observed 15.0% NO inhibition at 100 µM. Additionally, it has shown notable inhibition of velvetleaf seed germination, indicating herbicidal potential, and a high success rate (92.0%) in inhibiting pupation in Tenebrio molitor larvae. Furthermore, trans-Cinnamic acid inhibits HDAC activity in human Hela cells with significant potency (95.0% at 500 µM, Ki = 8.21 nM) and exhibits anticancer activities in multiple human cell lines including A549, A375, and MCF7, with IC50 values in the low micromolar range, notably 87 µM for A549 cells. It demonstrates potent xanthine oxidase inhibition (IC50 = 26.4 µg/mL) and moderate activity against Mycobacterium tuberculosis H37Rv (MIC = 675 µM). In terms of enzyme inhibition, trans-Cinnamic acid inhibits electric eel AChE (IC50 = 9900 µM) and human aldose reductase with 43.6% inhibition at 15 µM. It also shows antifungal, antibacterial, and nematicidal activities along with significant reduction of Pseudomonas aeruginosa quorum sensing (IC50 = 1680 µM). Additionally, it inhibits the mammalian GPR109a receptor (Ki = 4900 nM). The compound reveals antioxidant activity with DPPH radical scavenging (IC50 > 250,000 nM) and ORAC-FL assay results showing activity equivalent to 1.04 trolox equivalents at 10 µM. trans-Cinnamic acid also exhibits anti-inflammatory activity in mouse BV2 cells, neuroprotection in HT22 cells, and inhibition of osteoclast differentiation along with stimulation of osteoblastogenic activity in mouse MC3T3-E1 cells. Overall, trans-Cinnamic acid interacts with a variety of biological targets and demonstrates a broad spectrum of pharmacological activities, including cytoprotective, anti-inflammatory, antimicrobial, antioxidant, anticancer, herbicidal, and enzyme inhibitory effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.
Synonyms	trans-3-Phenylacrylic acid, Phenylacrylic acid, Isocinnamic acid, Cinnamylic acid, Cinnamic acid, 3-Phenylacrylic acid

Chemical Properties

Molecular Weight	148.16
Formula	C₉H₈O₂
Cas No.	140-10-3
Smiles	C(=C/C(O)=O)\C1=CC=CC=C1
Relative Density.	1.248

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (1636.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.7495 mL	33.7473 mL	67.4946 mL	337.4730 mL
5 mM	1.3499 mL	6.7495 mL	13.4989 mL	67.4946 mL
10 mM	0.6749 mL	3.3747 mL	6.7495 mL	33.7473 mL
20 mM	0.3375 mL	1.6874 mL	3.3747 mL	16.8737 mL
50 mM	0.1350 mL	0.6749 mL	1.3499 mL	6.7495 mL
100 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3747 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc